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For vaccines, the agency said that if a product that has already received emergency use authorization needs modification to address the variant, guidance recommends that a determination of efficacy be supported by data from clinical immunogenicity studies, which would compare a recipient’s immune response to virus variants induced by the modified vaccine against the immune response to the authorized vaccine. polo snow jacket AP Photo/Martin Meissner)prevImage 3 of 3In this 2012 photo, Kate and Gerry McCann pose for the media with a missing poster depicting an age progression computer generated image of their daughter Madeleine at nine years of age, to mark her birthday and the 5th anniversary of her disappearance during a family vacation in southern Portugal in May 2007, during a news conference in London. polo snow jacket ROYAL CARIBBEAN CLAIMS GRANDFATHER KNEW WINDOW WAS OPEN BEFORE TODDLER'S FATAL FALLAccording to the filing, both the Wiegand family and the Coast Guard made requests for the closed-circuit television footage surrounding the time of the incident in order to determine who opened the windows and why, and whether it was a crew member who should have been aware of Koopman's warnings. polo snow jacket CLICK HERE TO SIGN UP FOR OUR ENTERTAINMENT NEWSLETTERNo word yet from the streaming giant as to whether the program will receive a followup season, but less than two weeks after the show dropped, one of Netflix's Twitter accounts said that the series "is projected to court more than 63 million households, which would make it Netflix's fifth biggest original series launched to date. polo snow jacket